Tuesday, June 18, 2013

Seeking a Syria consensus despite US-Russia divide

G8 leaders from left, German Chancellor Angela Merkel, Russian President Vladimir Putin, Britain's Prime Minister David Cameron and US President Barack Obama attend a working session during the G-8 summit at the Lough Erne golf resort in Enniskillen, Northern Ireland on Tuesday, June 18, 2013. (AP Photo/Yves Herman, Pool)

G8 leaders from left, German Chancellor Angela Merkel, Russian President Vladimir Putin, Britain's Prime Minister David Cameron and US President Barack Obama attend a working session during the G-8 summit at the Lough Erne golf resort in Enniskillen, Northern Ireland on Tuesday, June 18, 2013. (AP Photo/Yves Herman, Pool)

G-8 leaders from left, European Commission President Jose Manuel Barroso, Japan's Prime Minister Shinzo Abe, German Chancellor Angela Merkel, Russian President Vladimir Putin, British Prime Minister David Cameron, US President Barack Obama, French President Francois Hollande, Canadian Prime Minister Stephen Harper, Italian Prime Minister Enrico Letta and European Council President Herman Van Rompuy pose during a group photo opportunity during the G-8 summit at the Lough Erne golf resort in Enniskillen, Northern Ireland, on Tuesday, June 18, 2013. The final day of the G-8 summit of wealthy nations is ending with discussions on globe-trotting corporate tax dodgers, a lunch with leaders from Africa, and suspense over whether Russia and Western leaders can avoid diplomatic fireworks over their deadlock on Syria?s civil war. (AP Photo/Matt Dunham)

President Barack Obama meets with Russian President Vladimir Putin in Enniskillen, Northern Ireland, Monday, June 17, 2013. Obama and Putin discussed the ongoing conflict in Syria during their bilateral meeting. (AP Photo/Evan Vucci)

US President Barack Obama, right, and Canadian Prime Minister Stephen Harper walk together to a group photo opportunity during the G-8 summit at the Lough Erne golf resort in Enniskillen, Northern Ireland, on Tuesday, June 18, 2013. The final day of the G-8 summit of wealthy nations is ending with discussions on globe-trotting corporate tax dodgers, a lunch with leaders from Africa, and suspense over whether Russia and Western leaders can avoid diplomatic fireworks over their deadlock on Syria?s civil war. (AP Photo/Lefteris Pitarakis)

G8 leaders from left, European Commission President Jose Manuel Barroso, Japan's Prime Minister Shinzo Abe, German Chancellor Angela Merkel, Russian President Vladimir Putin, Britain's Prime Minister David Cameron, US President Barack Obama, French President Francois Hollande, Canadian Prime Minister Stephen Harper, Italian Prime Minister Enrico Letta and European Council President Herman Van Rompuy attend a working session during the G-8 summit at the Lough Erne golf resort in Enniskillen, Northern Ireland on Tuesday, June 18, 2013. (AP Photo/Jewel Samad, Pool)

(AP) ? Hunting for a glimmer of common ground, the leaders of major economic powers are declaring themselves dedicated to a political solution to Syria's bloody civil war, even as President Barack Obama and Russian President Vladimir Putin stake out diametrically opposite stands on which side deserves military support.

Ahead of a Group of Eight joint statement on Syria to be issued Tuesday, the U.S. remained committed to Obama's recent decision to arm the rebels and Russia did not budge from its weapons sales to President Bashar Assad's regime.

Yet even as Obama found common ground among European allies against Putin at a G-8 summit in Northern Ireland, the U.S. president also struggled to convince some of those same allies to join him in sending armaments to the Syrian opposition.

Syria, where at least 93,000 people have been killed in the conflict, has emerged as one of the intractable issues at the G-8 in Northern Ireland, where leaders of eight of the wealthiest economies gathered at a gleaming lakeside golf resort to hash over trade, tax and foreign policy challenges.

"Of course, our opinions do not coincide, but all of us have the intention to stop the violence in Syria, to stop the growth of victims, and to solve the situation peacefully," Putin said after meeting for two hours with Obama. "We agreed to push the parties to the negotiations table."

"We do have differing perspectives on the problem," Obama concurred. "But we share an interest in reducing the violence; securing chemical weapons and ensuring that they're neither used nor are they subject to proliferation; and that we want to try to resolve the issue through political means, if possible."

In an interview on PBS that was taped Sunday and aired late Monday, Obama was much blunter, and pessimistic.

"What's been clear is that Assad, at this point ? in part, because of his support from Iran and from Russia ? believes that he does not have to engage in a political transition, believes that he can continue to simply violently suppress over half of the population," Obama told interviewer Charlie Rose. "And as long as he's got that mindset, it's going to be very difficult to resolve the situation there."

Even so, Obama in the interview portrayed himself as a reluctant participant in the civil war.

"We know what it's like to rush into a war in the Middle East without having thought it through," he said in obvious reference to the war in Iraq.

British officials said Cameron was looking for consensus among the G-8 members on five areas of potential agreement that could win Russian support, including securing chemical weapons, pursuing extremists and creating an executive authority for Syria after it undergoes a political transition.

But despite their shared belief that Assad must leave power, the U.S., Britain and France were also showing cracks in their unity. Britain and France appear unwilling ? at least for now ? to join President Barack Obama in arming the Syrian rebels, a step the U.S. president reluctantly finalized last week.

Ben Rhodes, Obama's deputy national security adviser, downplayed those differences, saying the Syrian opposition could be strengthened either politically, through humanitarian aid or as a military force.

"Different nations are going to feed into that process in different ways," he said.

The G-8 leaders were all smiles Tuesday morning as they walked in unison under cloud-covered skies at the lodge, where they posed for a "family photo" in front of a lake before Obama and Canadian Prime Minister Stephen Harper set off for a walk. Talks on how to combat corporate tax-dodging balanced out the effort to find some modicum of consensus on Syria in the waning hours of the summit as the leaders huddled in meetings and at a working lunch.

The sensitive Syria discussions unfolded in the midst of awkward revelations that the British eavesdropping agency GCHQ tapped into the communications of foreign diplomats during the 2009 Group of 20 summit in London, including those of Russian leader Dmitry Medvedev. That report, in the newspaper The Guardian, came on the heels of reports about the high-tech surveillance methods and record-gathering employed by the National Security Agency in the United States.

While the disclosures added a layer of controversy to the summit, U.S. officials said heads of state at a summit like the G-8 are perfectly aware that such spying goes on. As for the issue coming up in talks with Putin, deputy national security adviser Ben Rhodes told reporters, "It was a non-event at this meeting."

Indeed, in his interview with PBS, Obama made it clear such eavesdropping is commonplace, and tried to distinguish it from the cyber-hacking his administration has accused China of carrying out.

"There is a big difference between China wanting to figure out how can they find out what my talking points are when I'm meeting with the Japanese, which is standard fare, and we try to prevent them from penetrating that, and they try to get that information," he said. "There's a big difference between that and a hacker directly connected with the Chinese government or the Chinese military breaking into Apple's software systems to see if they can obtain the designs for the latest Apple product. That's theft."

It was a remarkably direct accusation coming just a week after Obama met with Chinese President Xi Jinping in a desert resort in California.

"We had a very blunt conversation about cybersecurity," Obama said of his talks with Xi.

With Putin, Obama also tried to emphasize their areas of cooperation, including an extension of a 1992 agreement designed to curtail the spread of nuclear weapons. The agreement resolved Russian concerns that the original post-Soviet pact, named after Senate sponsors Democrat Sam Nunn and Republican Richard Lugar, was too intrusive in securing material from Russia. Rhodes said the deal allows both countries to cooperate on nuclear security in the U.S. and Russia, but also in other countries. Obama is likely to draw attention to the deal in a speech Wednesday in Berlin.

Still, relations between Obama and Putin have never been warm. Rhodes called the encounter between the two "businesslike," one made even more stilted through translation.

Obama tried to leaven their joint appearance before reporters at the end of their talks by observing that "we compared notes on President Putin's expertise in judo and my declining skills in basketball. And we both agreed that as you get older it takes more time to recover."

Putin, through an interpreter, replied, "The president wants to relax me with his statement of age."

___

Associated Press writers Cassandra Vinograd and Julie Pace in Northern Ireland contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-06-18-EU-Obama/id-a517773e692745d8bbaffd859e1c5e07

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A Psychiatrist's Opinion about ADHD and Substance Use in ...

Five friends

Attention Deficit Hyperactivity Disorder (ADHD) and substance use problems have been gaining more attention in the news and in research over the last 7 months. Here are the most recent highlights about ADHD:

October 2012: The New York Times reports that pediatrician Michael Anderson treats patients?in a more impoverished Georgia county?with the stimulant Adderall. ?He calls [ADHD] ?made up? and ?an excuse? to prescribe the pills to treat what he considers the children?s true ill ? poor academic performance in inadequate schools.???I don?t have a whole lot of choice,? said Dr. Anderson. ?We?ve decided as a society that it?s too expensive to modify the kid?s environment. So we have to modify the kid.?

March 2013: The New York Times reports a study by the Federal Centers for Disease Control and Prevention showing ?nearly one in five high school age boys in the United States and 11 percent of school-age children overall have received a medical diagnosis of attention deficit hyperactivity disorder.? You should note that the only question asked of households with children was whether a physician diagnosed the child with ADHD. The article then reports on findings from other studies.?6.4 million children ages four through 17 at one time were ?diagnosed with ADHD,? which rose 16% since 2007 and 41 % over the past decade. Two-thirds of these children were treated with a stimulant. The Times article then printed a number of opinions, including those experts and administrators that overstate the problem or are not backed by research evidence:

  1. The stimulant medications ?can drastically improve the lives of those with?ADHD?but can also lead to addiction, anxiety and occasionally psychosis.?
  2. Mild symptoms are being diagnosed so readily, which goes well beyond the disorder and beyond the zone of ambiguity to pure enhancement of children who are otherwise healthy.?
  3. Medication advertising plays off the fears of parents and may lead to the rise in stimulant use. On the other hand, some respected researchers think that this data is inflated and overstates the prevalence of ADHD.

April 2013: The President-elect of the American Psychiatric Association denounces the Times article. He states that the current data may suggest that physicians may be either under diagnosing or over diagnosing ADHD. Furthermore, there were too many inaccuracies in the article, three of which were corrected in later versions.

May 18, 2013: The DSM-V is released, culminating a 14-year process of discussion and revision. The definition of ADHD is updated to take into account the fact that it can continue into adulthood. The criteria have not changed, still emphasizing that the symptoms must appear in multiple settings (home, school, work) and must result in performance problems, such as ?failure to pay close attention to details, difficulty organizing tasks and activities, excessive talking, fidgeting, or an inability to remain seated in appropriate situations.?

However, we clinicians know that?ADHD and substance use?can affect sobriety and recovery. We?call it ?double trouble.? So how should we react to this news?

Question & Answer format (a doctor interviewing himself):

Q: Is ADHD a real disease or just a way to control children who do not fit the norm?

A: We do not know how to answer this question, but here is what I think about it, 5-6% of children have ADHD, a more modest figure. They are called disordered, because they have a poor fit with their environment. They tend not to follow rules well, fail to achieve expectations, and get in more trouble with social institutions and families. ?This 5-6% is still a significant percentage for a disorder, higher than for schizophrenia. It could mean that?in earlier societies,?ADHD once had an adaptive purpose when tribes needed some individuals who were more distracted by sound, symbols, color and motion. These village kids took greater risks without thinking of the consequences. ?Wouldn?t you want these more impulsive, brave, hypersensitive souls hanging around to inform the tribe about approaching intruders and enemies? Now, with more sophisticated and complicated societies insuring greater safety, such children are seen as an annoyance rather than gifted. Some of the best researchers in my field first proposed this hypothesis back in 1997 (see below). The problem may be that ?we? have not respected these children for what they can contribute or found lasting ways to make them feel more welcome and competent.

Q: Is Doctor Anderson doing more harm than good or more good than harm?

A: It depends on the case, but overall I think he defeats his purpose.?He makes a good point, that our schools, communities and families let down these??wild and wooly children? and families by failing to create necessary and effective accommodations in terms of teaching, community activities, and parenting.? Then he potentially?puts underachieving children who have less?ADHD?criteria than required at risk by over treating them with powerful medications. This goes against one of basic principles in medicine ? ?First, do no harm?.? Dr. Anderson is also wrong in ignoring excellent diagnostic and treatment research that points to the validity of ADHD and the superior effectiveness of medication with adjunctive treatment (see below). ?He then takes a big chance, treating?in a vacuum?those without the full definition of a disorder, and without stating that the clinician must work closely with the child?s school, community and family.??The USA is a can-do country, but this doctor seems to be throwing up his hands and handing out prescriptions. Note: ?wild and wooly? is my non-professional depiction of kids with ADHD, most of whom I enjoy engaging and treating.

Q: Are we just diagnosing and treating to satisfy the pharmaceutical companies?

A: No, ?we? are not.??Both the American Association of Pediatrics and the American Academy of Child and Adolescent Psychiatry publish ?practice parameters? about ADHD that emphasize a biological, psychological and social approach to evaluation and treatment. Physicians, nurses, social workers, counselors, and therapists should be the leaders in the community pushing for rigorousness in making diagnoses and advocating for the humane treatment of ADHD children.

Q: Are we simply drugging the next generation of children and turning them into addicts?

A: No. ADHD is a real phenomenon.? The?ADHD?research indicates that we need to do better about intervening with children and teens to prevent substance abuse problems. 15-19% of patients with ADHD will start to?smoke or develop other?substance?abuse disorders, and even though stimulants?are a controlled?substance, a meta-analysis of open-label?long-term studies of stimulant treatment in ADHD?concluded that stimulant treatment does?not?increase?the risk of substance abuse and may even have a?protective effect.

One study that is important in addressing ADHA is the MTA?Study (Multimodal Treatment of Attention Deficit Hyperactivity Disorder), which was long-term, multi-site research to figure out what helps ADHD children. It showed that??combination treatment and medication management?alone were both significantly superior to intensive behavioral treatment alone and to routine community care in reducing ADHD symptoms. The study also showed that these benefits last for as long as 14 months?In other areas of functioning (e.g., anxiety? symptoms, academic performance, parent-child relations, and social skills), combination?treatment was consistently superior to routine community care, whereas medication alone or behavioral treatment alone were not. The children in the combination treatment also ended up taking lower doses of medication than the children in the medication-alone group.The MTA study also showed in an 8-year follow-up of ADHD children that ?treatment with?stimulants did not seem to have any?affect whatsoever on substance use or?the development of substance use disorders (SUDs). Children with ADHD, regardless of treatment, were at a greater risk?for SUDs.

The take home message

?The good news is that stimulants are not?increasing the risk for substance use disorders as some have suggested. The bad?news is that our treatment does not seem?to be doing much of anything to address?the elevated risk for SUDs in this vulnerable population,?despite the fact that stimulants provide?dramatic improvement in ADHD symptoms for 80% of the children to whom?they are prescribed. While disappointing, these results?will hopefully inspire us?as clinicians and researchers to develop?new ways, psychosocial or pharmacologic, to intervene with children with?ADHD to try to decrease and prevent?the onset of SUDs.?

A 10+ year follow-up of Minnesota children with ADHD (in school from 1976-82) showed that 29% continued to have the condition as adults. Those who no longer had the condition were still three times more likely to have a psychiatric diagnosis. 26.3% had?alcohol abuse or dependence and 16.4% had other substance abuse or dependence. The 29% who had ADHD into adulthood had almost six times the odds of having another psychiatric diagnosis.

The take home message

?It is concerning that only?a minority of children?with ADHD reaches adulthood without?suffering serious adverse outcomes,?suggesting that the care of childhood?ADHD is far from optimal. Our results?also indicate that clinicians, insurers, and?health care systems must be?prepared to?provide appropriate care for adults with?ADHD.?

The practice guidelines for ADHD suggest that we do the following:

  1. always assess for substance use disorders
  2. screen?older adolescents?with ADHD for?substance?abuse?disorders, as they are at greater risk than teenagers?without ADHD for smoking, alcohol and other?illegal substance abuse disorders
  3. consider non-potentially addicting agents for ADHD (such as atomoxetine, bupropion), if there is active addiction
  4. address generalized family dysfunction (parental?depression,?substance?abuse, marital problems),?so that psychosocial or?medication treatment is fully effective for the child with?ADHD

In conclusion, I propose that we know how to diagnose ADHD and we know what treatment works, but we need to apply it in the context of?the?community and the family. This takes work, backed by a can-do spirit. Diagnosis and treatment with medication alone may help, but does not respect the?talents, energy and the creativity of these unique?children. As a prescribing psychiatrist who is also certified in addiction medicine, I will only continue to chase my tail, trying to medicate ?wild and wooly? behavior, without including motivational therapy, family-focused and parent-focused interventions, school collaboration and consultation, and community reinforcement of pro-social behaviors. Therefore, prescribing a stimulant to an underachieving child is the last thing I think about doing.

Peter R. Cohen MD

Dr. Cohen is a board certified child and adolescent psychiatrist with additional certification in addiction medicine. He has written extensively about adolescent addiction and recovery, in addition to writing the Hazelden book, ?Helping Your Chemically Dependent Teenager Recover.? He has also served as the behavioral health medical director for Montgomery County, Maryland and the medical director for Maryland?s Alcohol and Drug Abuse Administration. He is semi-retired, but serves as the psychiatrist for emotionally challenged senior high students at the Foundation Schools in Largo, Maryland.

References:

1.?Attention Disorder or Not, Pills to Help in School, New York Times, Alan Schwartz,?October 9 2012

http://www.nytimes.com/2012/10/09/health/attention-disorder-or-not-children-prescribed-pills-to-help-in-school.html?pagewanted=all&_r=1&

2.?A.D.H.D. Seen in 11% of U.S. Children as Diagnoses Rise, New York Times, Alan Schwartz & Sarah Cohen, March 31, 2013

http://www.nytimes.com/2013/04/01/health/more-diagnoses-of-hyperactivity-causing-concern.html?pagewanted=1

3.?APA President-Elect Denounces Times Article on ADHD, Psychiatric News Alert, April 1, 2013

http://alert.psychiatricnews.org/2013/04/apa-president-elect-denounces-times.html

4. Attention Deficit/Hyperactivity Disorder Fact Sheet, American Psychiatric Publishing 2013

http://www.dsm5.org/Documents/ADHD%20Fact%20Sheet.pdf

5.?Practice Parameter for the Assessment and Treatment?of Children and Adolescents With Attention-Deficit/Hyperactivity Disorder,?American Academy of Child and Adolescent Psychiatry, 2007

http://download.journals.elsevierhealth.com/pdfs/journals/0890-8567/PIIS0890856709621821.pdf

6. ADHD Practice Guidelines of the American Academy of Pediatrics, January 2013.

http://www.cdc.gov/ncbddd/adhd/guidelines.html

7.?Evolution and Revolution in Child Psychiatry: ADHD as a Disorder of Adaptation, Peter Jensen, David Marazek et al, Journal of the American Academy of Child & Adolescent Psychiatry, 36:12,

December 1997, Pages 1672?1681

8.?The?MTA?Study (Multimodal Treatment of Attention Deficit Hyperactivity Disorder), NIMH, 1999-today

http://www.nimh.nih.gov/health/trials/practical/mta/the-multimodal-treatment-of-attention-deficit-hyperactivity-disorder-study-mta-questions-and-answers.shtml

9.?Mortality,?ADHD, and psychosocial adversity in adults?with childhood ADHD: a prospective study.?Pediatrics,?Barbaresi WJ, Colligan RC, et al.,?2013,?2012-2354?(thanks to Stuart Goldman MD, AACAP News, May/June 2013)

10.?Adolescent substance use in the?multimodal treatment study of attention deficit/hyperactivity disorder (ADHA) (MTA)?as a function of childhood ADHD, randomassignment to childhood treatments, and?subsequent medication. Molina BS, Hinshaw SP?et?al.?J Am Acad Child?Adolesc Psychiatry?52(3):250-63(2013).?(thanks to Stuart Goldman MD, AACAP News, May/June 2013)

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Source: http://www.danyainstitute.org/2013/06/a-psychiatrists-opinion-about-adhd-and-substance-use-in-teenagers-first-do-no-harm/?utm_source=rss&utm_medium=rss&utm_campaign=a-psychiatrists-opinion-about-adhd-and-substance-use-in-teenagers-first-do-no-harm

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Supreme Court Strikes Down Arizona Voting Law (Taegan Goddard's Political Wire)

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Video: Charlie Rose With President Obama on Syria, Iran, and NSA Leaks (Little green footballs)

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Monday, June 17, 2013

Raytheon's updated JTACs situational awareness system eyes-on (video)

Raytheon's updated JTACs system lets soldiers call in airstrike targets by looking at them

Though you may think drones do all the fighting these days, actual soldiers on the ground are still used to call in airstrikes. Sometimes it's still necessary to visually confirm targets before the flyboys create a smoking crater. Though the army has toyed with smartphones and other means to connect soldiers, Raytheon has created a new JTACs (Joint Tactical Air Controller system) prototype for ground forces to let them separate friendlies from enemies and relay the information to strike forces. The system consists of a chest-worn computer, heads-up monocle viewer and wrist-worn display, which together let the solider select a target merely by looking at it and pressing a button. They can also tag friendly forces the same way or send update situational data to the rest of the team, whether they're on the ground or flying a fighter overhead. That assistance from the ground will make it easier for those at the yoke to differentiate between friendlies and targets.

We tried the prototype ourselves in a limited, 2D environment here at the 2013 Paris Air Show and, without any help getting set up, were able to tag targets as red diamonds and friendly forces as amber squares. Everything we did was also displayed on second screen, simulating the ability to send live updates to other soldiers or the base. Impressive as it was, the whole thing is merely a prototype for now, though, that could eventually change. The military AR system is part of a larger platform called AWARE, which Raytheon hopes to eventually deploy. For a detailed explanation about how it works, check out the video after the break.

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Source: http://www.engadget.com/2013/06/17/raytheons-updated-jtacs-situational-awareness-system-eyes-on/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Jack Johnson pulls off the switch at Bonnaroo

MANCHESTER, Tenn. (AP) ? Nicely done, Jack Johnson.

Johnson and his band overcame tough odds and thorny logistics to headline the Bonnaroo Music & Arts Festival on Saturday night, replacing late cancellation Mumford & Sons. Despite the short notice, they produced a set filled with good humor, mellow vibes and a ton of hits.

"We want to dedicate this whole set to Ted Dwane and all of Mumford & Sons," Johnson said after taking the stage before tens of thousands of fans. "And we wish we could all be here playing music together. Maybe that will be next year."

Mumford & Sons was forced to pull out of its much-anticipated headline slot on Thursday after bassist Dwane underwent a surgical procedure earlier in the week to treat a blood clot on his brain. The group had hoped to keep the date in Manchester. Though Dwane is recovering, he was not ready to perform and the group was unwilling to take the stage with a replacement, leaving a large amount of money on the table.

There was much speculation among Bonnaroo organizers and watchers about how fans would react to the switch ? the first headliner cancellation in 12 years of Bonnaroo. But Johnson quickly won over the crowd and kept its fickle attention with a light touch and his easygoing persona.

"Give us that one," Johnson joked after a flub late in the set. "We practiced for a couple of hours."

Bonnaroo 2013 turned out quite differently from what Johnson was expecting. He hasn't played the festival since 2008 and was in town to do a little light promotion for his new album, "From Here To Now To You," out in September, and to appear with his friends in ALO.

He got a phone call Thursday as he drove to the festival from organizers wondering whether he'd be interested in upping his involvement.

After thinking about it, Johnson flew in his band, rehearsed some Friday night, attended a breakfast with fans in Nashville on Saturday morning and then prepped for the show. It's been two years since the four-piece played a long set, convening for just 45 minutes last year at Farm Aid.

About the only thing that seemed the worse for wear were the 38-year-old Hawaiian singer's trademark curls, which unraveled in middle Tennessee's oppressive humidity.

Heck, Johnson even had time to write a new song called "Bonnaroo" for the set, singing in part: "I had a late-night gig with ALO/It was very low stress, it was very low pro/But then the phone rang and things got strange/And my low pro was about the change/Can you get the band together in two days to play a show up on the big stage?/But I don't know, it's been a year or two since we played these tunes/What the hell, it's Bonnaroo."

A little later in the set he incorporated Mumford's "The Cave" into a medley with his song "Go On," telling the crowd: "Maybe you guys can help us with this part."

For those not into Johnson, there were plenty of other options on an exceedingly busy Saturday night that included appearances by British punker Billy Idol, Weird Al Yankovic and the Rock 'n' Soul Dance Party Superjam with Jim James and John Oates.

Mumford & Sons' folk-rock cousins The Lumineers drew one of the festival's largest crowds before Johnson took the stage. It was so large, in fact, fans on the edge of the crowd couldn't hear the band's mostly hushed, acoustic songs.

"Everybody be quiet, I'm trying to hear the band," one fan yelled as The Lumineers possibly performed a Bob Dylan song.

R&B singer R. Kelly had no trouble getting attention, though. He began his post-Johnson set by bringing dozens of chorus members on stage for a rendition of his song "Ignition." Suddenly the lights went dark and Kelly was illuminated 40 feet above, standing in the basket of a crane that hovered over the Which Stage's distinctive question mark symbol.

"They told me back stage there's no cursing here," Kelly told the crowd a little later. "I just laughed. I can't (expletive) curse?"

___

Online:

http://bonnaroo.com

____

Follow AP Music Writer Chris Talbott: http://twitter.com/Chris_Talbott.

Source: http://news.yahoo.com/jack-johnson-pulls-off-switch-bonnaroo-053418146.html

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Mapping translation sites in the human genome

June 16, 2013 ? Because of their central importance to biology, proteins have been the focus of intense research, particularly the manner in which they are produced from genetically coded templates -- a process commonly known as translation. While the general mechanism of translation has been understood for some time, protein synthesis can initiate by more than one mechanism. One of the least well understood mechanisms is known as cap-independent translation.

Now, John Chaput and his colleagues at Arizona State University's Biodesign Institute have produced the first genome-wide investigation of cap-independent translation, identifying thousands of mRNA sequences that act as Translation Enhancing Elements (TEEs), which are RNA sequences upstream of the coding region that help recruit the ribosome to the translation start site.

The new study outlines a technique for mining whole genomes for sequences that initiate cap-independent translation within the vastness of the genome.

The research has important implications for the fundamental understanding of translation in living systems, as well as intriguing potential in the biomedical arena. (Many viral pathogens are known to use cap-independent translation to hijack and redirect cellular mechanisms to translate viral proteins.)

The lead author of the study is Brian P. Wellensiek, a senior scientist in Biodesign's Center for Evolutionary Medicine and Informatics. The group's results appear in the current issue of the journal Nature Methods.

During most protein synthesis in eukaryotic cells, cap-dependent translation dominates. The process begins after DNA is first transcribed into mRNA, with the aid of an enzyme polymerase. mRNA now forms the coded template from which the translated proteins will be generated. The mRNA code consists of sequences made from 4 nucleic acids, A, C, G & U, with each 3-letter grouping (known as a codon), corresponding to one amino acid in the protein being synthesized.

A key component in the translation process is the ribosome, which migrates along the single stranded mRNA, reading the codons as it goes. Before it can do this however, it must locate a special structure at the 5' end of the mRNA strand known as the cap. In normal cap-dependent translation, the ribosome is recruited to the 5' end of mRNA via a specialized cap-binding complex.

Cap-independent translation allows the ribosome to begin reading the mRNA message without having to first locate the 5' cap structure. Cap-independent translation occurs in eukaryotic cells during normal processes including mitosis and apoptosis (or programmed cell death). It is also a feature in many forms of viral translation, where the viral transcript is able to recruit the ribosome and co-opt its function to preferentially translate viral RNA.

In the current study, Chaput designed an in vitro selection strategy to identify human genome sequences that initiate cap-independent translation. The technique is able to select candidates from a pool of trillions of genomic fragments. Once a set of sequences was identified as translation enhancing elements, they were shown to function effectively in both cell-free and cellular translation systems.

As Chaput explains, most research on cap-independent translation has been conducted using RNA fragments derived from viruses. "These RNA molecules will fold into shapes that appear to mimic some of the initiation factors that that you would find in eukaryotic translation," he says. More recently, similar RNA molecules have been identified in cellular systems, though the sequences tend to be much shorter and function in a different manner.

Chaput's method of studying such sequences on a genome-wide scale involves first generating a DNA library of the entire human genome. Using enzymes, the genome is cut into random fragments of around 200 base pairs each. These sequences are then transcribed into mRNA.

Applying a technique known as mRNA display, the fragments are tagged in specific way, such that amino acid sequences resulting from successful translation events remain bound to the mRNA fragments that generated them. "Essentially, what we're doing is taking a library of human mRNA and tagging those sequences that act as translation enhancing elements," Chaput says. Those sequences bearing an attached peptide affinity tag can then be separated out from the remaining untranslated sequences, reverse transcribed, amplified using PCR technology and subjected to subsequent rounds of selection.

The sequences were later mapped onto the human genome. As expected, the complete library of sequences used at the start of the experiments mapped fairly evenly across the genome. But the sequences selected via mRNA display as translation enhancing elements tended to cluster in non-coding regions of the genome. The authors speculate that such sequences may have been evolutionarily selected against, as they have the potential to disrupt normal cap-dependent translation.

Roughly 20 percent of the translation enhancing elements functioned as internal ribosomal initiation sites, again turning up primarily in non-coding genomic regions. The origin of these sequences remains mysterious. It is conceivable that they were surreptitiously brought on board as a result of human interaction with different types of viruses.

Once Chaput's group had acquired a library of 250 distinct translation enhancing elements through selection using mRNA display, the sequences were screened for translation enhancing activity, which was quantified using a light based assay employing a luciferase reporter molecule.

By measuring levels of luciferase, the enhancement of each sequence could be assessed relative to background noise, with the better translation enhancing elements displaying 50-100 fold enhancement (and some as much as 1000-fold enhancement). The next step was to determine which of these sequences could function as internal ribosomal initiation sites.

To do this, the same 250 sequences were inserted into a vector bearing a hairpin structure. As Chaput explains: "If the ribosome latched onto the 5' end, it would hit that hairpin and would fall off. However if the ribosome skipped the hairpin and recognized the sequence on the other side of the hairpin independently and translated it, that's an indication that the sequence is functioning as an internal ribosomal initiation site." Both assays (for translation enhancement and internal ribosomal initiation) were validated under cell-free conditions and in human cells, using a vaccinia virus vector.

A study of this scope is possible thanks to innovative techniques for in vitro selection (such as mRNA display), as well as a revolutionary technology permitting massively parallel RNA sequencing (known as deep sequencing), which provides unprecedented speed and read accuracy.

Much remains to be learned about atypical translation processes. The mechanism of action for translation enhancing elements is still obscure, particularly in the case of internal ribosomal initiation sites. Similarly, the particular gene products that may result from cap-independent translation have yet to be identified and characterized.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/giXLkqwIWhM/130616155211.htm

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Sunday, June 16, 2013

Moderate cleric wins Iran's presidential vote

TEHRAN, Iran (AP) ? Moderate cleric Hasan Rowhani was declared the winner of Iran's presidential vote on Saturday after gaining support among many reform-minded Iranians looking to claw back a bit of ground after years of crackdowns and now resets the country's political order.

The stunning surge behind Rowhani, a former nuclear negotiator, was seen by his supports as a rebuke of uncompromising policies that have left Iran increasingly isolated and under biting sanctions from the West over Tehran's nuclear program. It also demonstrated the strength of opposition sentiment even in a system that is largely organized against it.

The ruling clerics barred from the race reform candidates seen as too prominent, allowing a list of hopefuls who were mainly staunch loyalists of the supreme leader and the Islamic establishment. But the opposition settled on the 64-year-old Rowhani as the least objectionable of the bunch, making him a de facto reform candidate with backers inspired by his message of outreach rather than confrontation.

Celebrations broke out across Tehran and other cities. Thousands of Rowhani supporters took to the streets leading to his campaign headquarters in Tehran before the final results were announced despite a statement from Rowhani urging his supporters to avoid street gatherings. There were no immediate reports of unrest or attempts by security forces to rein in the crowds ? another sign of the sweeping scope of Rowhani's victory with more than three times as many votes as his nearest rival.

But the numbers don't translate directly into power in Iran's Islamic system. The ruling clerics and their protectors, the Revolutionary Guard, maintain control over all key decisions such as nuclear efforts, the military and foreign affairs.

What Rowhani's victory means, however, is that reformists and liberals will likely regain a greater voice and clout to try to shape the views of the theocracy, which cannot easily ignore the decisive outcome of Friday's election to success the combative Mahmoud Ahmadinejad. He was barred from seeking a third consecutive run.

Ahmadinejad congratulated Rowhani, adding "I hope ... opportunity will be provided more than before to serve and work for the establishment of justice and development of the country."

Rowhani won with 50.7 percent of the more than 36 million votes cast, the Interior Ministry reported, well ahead of Tehran Mayor Mohammad Bagher Qalibaf with about 16.5 percent. Hard-line nuclear negotiator Saeed Jalili ? who said he was "100 percent" against detente with Iran's foes ? came in third with 11.3 percent followed by conservative Mohsen Rezaei with 10.6 percent.

Minister Mostafa Mohammad Najjar said the turnout was 72.7 percent, suggesting that liberals and others abandoned a planned boycott as the election was transformed into a showdown across the Islamic Republic's political divide. Iran has more than 50 million eligible voters.

Rowhani just cleared the majority needed to seal victory and avoid a runoff. The Interior Ministry said Rowhani had 18,613,329 votes, followed by Qalibaf with 6,077,292, Jalili with 4,168,946 votes and Rezaei with 3,884,412. The other two candidates were far behind.

Rowhani, the only cleric in the race, led the influential Supreme National Security Council and was given the highly sensitive nuclear envoy role in 2003, a year after Iran's 20-year-old atomic program was revealed.

"Rowhani is not an outsider and any gains by him do not mean the system is weak or that there are serious cracks," said Rasool Nafisi, an Iranian affairs analyst at Strayer University in Virginia. "The ruling system has made sure that no one on the ballot is going to shake things up."

Yet the last campaign events for Rowhani carried chants that had been bottled up for years.

Some supporters called for the release of political prisoners including opposition leaders Mir Hossein Mousavi and Mahdi Karroubi, both candidates in 2009 disputed election and now under house arrest. "Long live reforms," some cried at Rowhani's last rally. The rally was awash in purple banners and scarves ? the campaign's signature hue in a nod to the single-color identity of Mousavi's now-crushed Green Movement.

In the end, it appeared ideology overcame the economy as a deciding factor. Many voters had indicated they could favor Qalibaf because of his reputation as a competent fiscal steward who could help stabilize Iran's sanctions-battered economy.

Western sanctions over Iran's nuclear program have shrunk vital oil sales and are leaving the country isolated from international banking systems. New U.S. measures taking effect July 1 further target Iran's currency, the rial, which has lost half its foreign exchange value in the past year, driving prices of food and consumer goods sharply higher.

"I cordially congratulate your deserving election as the president of the Islamic Republic of Iran and demand the God almighty to bestow you and your future government success in serving the honorable Iranian people," Qalibaf said in a message addressed to Rowhani.

Just a week ago, Rowhani was seen as overshadowed by candidates with far deeper ties to the current power structure: Jalili and Qalibaf.

Then a moderate rival of Rowhani bowed out of the presidential race to consolidate the pro-reform camp. That opened the way for high-profile endorsements including his political mentor, former President Akbar Heshmi Rafsanjani, who won admiration from opposition forces for denouncing the postelection crackdowns in 2009. This, too, may have led to Rafsanjani's being blackballed from the ballot this year by Iran's election overseers, which allowed just eight candidates among more than 680 hopefuls.

Iran's supreme leader, Ayatollah Ali Khamenei, did not publicly endorse a successor for Ahmadinejad following their falling out over the president's attempts to challenge Khamenei's near-absolute powers.

Khamenei praised Iranians for the high turnout, calling it an "epic and enthusiastic election" and a "dazzling test."

"After weeks of speaking and hearing, it's time to work. The president-elect, until formally taking office, has a precious opportunity ... to begin without hesitation the work that presidential responsibilities require," he said in his message broadcast on state TV.

Iran's stock exchange and currency markets reacted positively to early election results that showed Rowhani ahead.

The stock exchange index rose 2 percent while the rial strengthened by 9 percent against the U.S. dollar.

___

Murphy reported from Dubai, United Arab Emirates. Associated Press writer Nasser Karimi in Tehran contributed to this report.

Source: http://news.yahoo.com/moderate-cleric-wins-irans-presidential-vote-164644333.html

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Q10 could give BlackBerry a huge boost

By Jonathan Stempel (Reuters) - A South Dakota meat processor that sued ABC News over a series of reports that called its signature product "pink slime" has won the right to move its $1.2 billion defamation and product disparagement lawsuit back to the state court where it began. Wednesday's decision to move the case by U.S. District Judge Karen Schreier in Sioux Falls, South Dakota, is a defeat for ABC News, a unit of Walt Disney Co, and returned the lawsuit by Beef Products Inc (BPI) and two affiliates back to the Union County Circuit Court in that state. ...

Source: http://news.yahoo.com/q10-could-blackberry-huge-boost-191030091.html

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Game on: Console war heats up this fall - MarketWatch

By Dan Gallagher, MarketWatch

Visitors crowd the booths of Microsoft and Sony at the E3 videogame conference in Los Angeles in order to try the Xbox One and PlayStation 4 ? both of which due to hit the market this fall.

SAN FRANCISCO (MarketWatch) ? More than 48,000 people crowded into a Downtown Los Angeles venue this week to get an early peek at the Xbox One and PlayStation 4, as well as the high-profile videogames that will be available for the consoles over the next several months.

Attendance at the Electronic Entertainment Expo, or E3, was up about 5.5% this year, according to figures released Thursday by the Electronic Software Association, which sponsors the conference. That reversed last year?s 2% slip in attendance, and was likely driven by interest in the two new high-definition gaming consoles due to hit the market this fall.

Game consoles vs. mobile gaming

Sony releases long-awaited details about its coming PlayStation 4 at the Electronic Entertainment Expo, as it seeks to differentiate itself from mobile-gaming competitors.

As far as drawing buzz, the conference did not disappoint. Sony Corp. /quotes/zigman/197524/quotes/nls/sne SNE -5.47% ? /quotes/zigman/197500 JP:6758 -0.36% ?in particular sprung a surprise by announcing a $399 price tag for the PlayStation 4, which was $200 below the introductory price for its predecessor console and $100 below the launch price Microsoft /quotes/zigman/20493/quotes/nls/msft MSFT -0.91% announced for the Xbox One.

Investors and analysts largely cheered Sony for the move, sending the U.S.-listed shares of the Japanese electronics giant up more than 7% this week, while Microsoft?s shares have slipped more than 2% since the start of the conference. Still, the Xbox business still makes up only a small portion of Microsoft?s overall revenue compared to its Windows and Office businesses, while Sony too is large conglomerate with wide electronics and entertainment interests.

Sony was also commended for taking a ?pro-gamer? stance on the issues of playing used games on the new console and always-on Internet connectivity ? stating clearly that used games would not be limited, and gamers would not have to keep the console connected to the Internet if they didn?t want to.

Microsoft has said it will leave the question of fees for used games up to the publishers, but that the Xbox One will need frequent connections to the Web to work.

?Microsoft has officially stubbed its toe,? Evan Wilson of Pacific Crest wrote in a note to clients on Thursday, adding that ?the Xbox One now has a problem on its hands as far as initial sales are concerned, although there is still much to be decided.?

In a note Friday morning, Michael Pachter of Wedbush Securities wrote that ?Xbox One?s higher price point and Microsoft?s approaches to used gaming and ?always on? will likely cost Xbox One some market share in the first year or so of the cycle,? adding that Sony was ?the clear winner of this year?s E3.?

Investors have bid up the stocks of game publishers such as Electronic Arts /quotes/zigman/71356/quotes/nls/ea EA +1.49% ?, Activision Blizzard /quotes/zigman/110164/quotes/nls/atvi ATVI +0.34% ?, Take-Two Interactive /quotes/zigman/62747/quotes/nls/ttwo TTWO -0.26% and Ubisioft /quotes/zigman/163953 FR:UBI -0.58% ? ? as well as retailer GameStop /quotes/zigman/389699/quotes/nls/gme GME +3.94% ? since the first of the year, in the hopes that the new consoles will spark game sales.

Xbox One will boast extensive entertainment options

As the looming console war between Sony and Microsoft begins to heat up, the Xbox One teams stress the added value of their product being an "all-in-one entertainment solution."

But questions remain as to whether or not this will actually happen. Despite a surprisingly lower price for the PS4, each console represents an investment of several hundred dollars ? as well as $60 per game ? in an era when smartphones, tablets and social networks are offering thousands of game for free.

?I?m skeptical. I don?t think either platform has definitely convinced many as to why they need to spend so much money on a new gaming platform,? Colin Sebastian of Robert W. Baird told MarketWatch.

Wilson of Pacific Crest was even more bearish, predicting on Thursday that ?we now think this cycle may be the first down cycle for hardware.?

Others are more positive. Arvind Bhatia of Sterne Agee wrote Wednesday that ?we think there is a good chance of double-digit next-gen console unit growth in the initial years,? when compared to the same point in the previous console cycle.

Both new consoles are expected to launch this fall, but no specific dates have yet been given.

/quotes/zigman/197524/quotes/nls/sne

US : U.S.: NYSE

Volume: 5.96M

June 14, 2013 4:00p

/quotes/zigman/197500

JP : Japan: Tokyo

Volume: 22.13M

June 14, 2013 3:00p

Market Cap

?1945.98 billion

/quotes/zigman/20493/quotes/nls/msft

US : U.S.: Nasdaq

Volume: 46.29M

June 14, 2013 4:00p

Market Cap

$287.28 billion

Rev. per Employee

$806,245

/quotes/zigman/71356/quotes/nls/ea

US : U.S.: Nasdaq

Volume: 3.56M

June 14, 2013 4:00p

Rev. per Employee

$408,280

/quotes/zigman/110164/quotes/nls/atvi

US : U.S.: Nasdaq

Volume: 3.98M

June 14, 2013 4:00p

Rev. per Employee

$747,463

/quotes/zigman/62747/quotes/nls/ttwo

US : U.S.: Nasdaq

Volume: 1.83M

June 14, 2013 4:00p

Rev. per Employee

$497,739

/quotes/zigman/163953

FR : France: Paris

Volume: 185,843

June 14, 2013 3:37p

Market Cap

?983.60 million

Rev. per Employee

?187,824

/quotes/zigman/389699/quotes/nls/gme

US : U.S.: NYSE

Volume: 6.05M

June 14, 2013 4:01p

Rev. per Employee

$514,694

Dan Gallagher is MarketWatch's technology editor, based in San Francisco. Follow him on Twitter @MWDanGallagher.

Source: http://www.marketwatch.com/story/game-on-console-war-heats-up-this-fall-2013-06-14

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Saturday, June 15, 2013

Officials: NSA programs broke plots in 20 nations

WASHINGTON (AP) ? Top U.S. intelligence officials say information gleaned from two controversial data-collection programs run by the National Security Agency thwarted potential terrorist plots in the U.S. and more than 20 other countries.

No other new details about the plots or the countries involved are part of newly declassified information released to Congress on Saturday and made public by the Senate Intelligence Committee.

Intelligence officials say that fewer than 300 phone numbers were checked last year against the database of millions of U.S. phone records gathered daily by the NSA. Under the program, the records can only be examined for suspected connections to terrorism.

Also revealed: The Foreign Intelligence Surveillance Court reviews the two data-collection programs every 90 days, and the data gathered must be destroyed every five years.

Source: http://news.yahoo.com/officials-nsa-programs-broke-plots-20-nations-233703820.html

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FDA Calls On Medical Devicemakers To Focus On Cybersecurity

Insulin pumps and glucometers, in particular, can be...

Not just those, but cardiac implants as well, which go beyond the "pacemaker" of yesterday and include defibrillator and cardiac resync therapy, (CRT), functionality as well. Recording heart function for review is very useful. One problem with this sort of vulnerability is that some might choose to forego the device, and therefore forego a better quality of life, for fear of someone fucking with the device just for the lulz.

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/tm6cbZ_nANk/story01.htm

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Friday, June 14, 2013

Decorating wedding venues with awesome themes for experiencing best results | Toronto Wedding Party and Decorations

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Source: http://youmob.com/mob.aspx?mob=http://torontoweddingparty.wordpress.com/2013/05/31/decorating-wedding-venues-with-awesome-themes-for-experiencing-best-results

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Lawmaker accuses Google of dodging taxes

LONDON (AP) ? An influential committee of British lawmakers accused search company Google of dodging its taxes on Thursday in a scathing report that said the U.S. Internet company took on highly contrived arrangements serving no purpose other than to avoid paying its fair share.

The report came after testimony by Google Inc. Vice President Matt Brittin, who tried to persuade members of parliament's Public Accounts Committee that his company was transparent and fair. Committee chair Margaret Hodge rejected arguments that Google's advertising sales take place in Ireland and not the U.K.

"Google brazenly argued before this committee that its tax arrangements in the U.K. are defensible and lawful," she wrote, adding that the "argument is deeply unconvincing and has been undermined by information from whistleblowers, including ex-employees of Google, who told us that U.K.-based staff are engaged in selling."

Hodge said the government needs to act to shut down loopholes.

"The company's highly contrived tax arrangement has no purpose other than to enable the company to avoid U.K. corporation tax," she said.

Google countered on Thursday that while it welcomed the call to make the system simpler and more transparent, the company was honoring the law.

"As we've always said, Google complies with all the tax rules in the U.K., and it is the politicians who make those rules," the company said in a statement. "It's clear from this report that the Public Accounts Committee wants to see international companies paying more tax where their customers are located, but that's not how the rules operate today."

Britain is in tough economic times, struggling with austerity measures that have led to cuts in welfare programs, public-sector jobs and government spending.

Like several other multinational corporations, including Amazon, Facebook and Starbucks, Google's complex corporate structures and disproportionately low tax bills have drawn the ire of a public facing one of the worst economic crises since the Great Depression.

Google has paid less than 0.1 percent of its billions in U.K. revenue back to the government in tax. In the first quarter of this year, it made $1.3 billion in revenue from the U.K., according to a Google release. The company argues that the overwhelming majority of sales actually occur at the company's European head office in Dublin.

The location is important. In Ireland, the corporate tax rate is a bargain-basement 12.5 percent.

An investigation by the Reuters news agency cast doubt on those claims, and the committee asked to speak to Brittin for a second time.

Brittin acknowledged that Google Inc. employed "people with sales skills," but insisted that those doing the sales are in Ireland.

Hodge rejected the characterization.

"Google's reputation has been damaged by these revelations of aggressive tax avoidance," she said. "That damage will not be repaired until the company arranges to pay its fair share of tax in the country where it earns the profits from the business it conducts."

Source: http://news.yahoo.com/lawmaker-accuses-google-dodging-taxes-065701089.html

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